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Porcine Circovirus Associated Disease : ウィキペディア英語版 | Porcine Circovirus Associated Disease Porcine Circoviral Disease (PCVD) and Porcine Circovirus Associated Disease (PCVAD), is a disease seen in domestic pigs. This disease causes illness in piglets, with clinical signs including progressive loss of body condition, visibly enlarged lymph nodes, difficulty in breathing, and sometimes diarrhea, pale skin, and jaundice.〔 PCVD has been reported from most pig-producing countries of the world at huge cost to agriculture. PCVD is caused by porcine circovirus type 2 (PCV2). PCVD was formerly named Postweaning multisystemic wasting syndrome ("PMWS") .〔 Because PCVD can cause other diseases other than PMWS and the "waste" may has negative impact on perceptions of the industry from consumers. The North American industry endorses "PCVAD" and European use "PCVD" to describe this disease. ==PMWS & PCV2== PCV-2 (first isolated in 1997) causes PMWS.〔 PCV2 has a near universal distribution – present in most pig herds. In contrast, PMWS is more sporadic in its distribution. Experimental induction of PMWS has not been achieved by PCV2 infection alone, using infectious DNA clones of the virus or a pure form of PCV2 derived from infectious DNA clones. Therefore it is assumed that PMWS is a multifactorial disease. PCV-2 is necessary but not sufficient for the development of PMWS. However, viral infection by itself tends to cause only mild disease, and co-factors such as other infections or immunostimulation seem necessary for development of severe disease.() For example, concurrent infection with porcine parvovirus or PRRS virus, or immunostimulation lead to increased replication of PCV-2 and more severe disease in PCV-2-infected pigs.〔 There is no significant correlation of the disease with virus sequence variation with affected and control pigs.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Porcine Circovirus Associated Disease」の詳細全文を読む
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